Overall Teaching Experience: 9 years

Research Experience:

Ph.D in Biochemistry (University of Calcutta) on Tumor cell – Extracellular matrix (ECM) crosstalk. The areas of work involves:-

• Studying the pro-metastaic effects of extracellular matrix components on different human cancer cell lines.
• Finding correlation of expression status of MMP, fibronectin and integrin with cancer progression .
• Studying effects of natural drug on MMP-9 and related signaling molecules in cancer cell line.
  

Publication in journal (Best 5):

1)      Pal, S.; Ganguly, K. K.; Chatterjee, A. Extracellular matrix protein fibronectin induces matrix metalloproteinases in human prostate adenocarcinoma cells PC-3. Cell Commun Adhes, 2013, 20: 105-114. (ISSN: 1541-9061) .

2)      Pal, S.; Ganguly, K. K.; Moulik, S.; Chatterjee, A. Modulation of MMPs by cell surface integrin receptor α5β1. Anti-cancer Agents in Medicinal Chemistry, 2012, 12 (7): 726-732. (ISSN: 1871-5206)

3)   Pal, S.; Moulik, S.; Dutta, A.; Chatterjee, A. Extracellular matrix protein laminin induces matrix metalloproteinase-9 in human breast cancer cell line MCF-7. Cancer Microenvironment, 2014, 7:71-78 (ISSN: 1875-2292).

4)   Pal, S.; Ganguly, K. K.; Chatterjee, A. Effect of Curcumin on Cell- ECM Interaction in Human Breast Cancer Cells MDA-MB-231. Biosc.Biotech.Res.Comm April-May-June 2020, 13 (2): 516-521. (ISSN: 0974-6455)

5) Ganguly, K. K.; Pal, S.; Moulik, S.; Chatterjee, A. Integrins and metastasis. Cell Adh Migr, 2013, 7: 251-261. (ISSN: 1933-6918)

Publication in Book chapter: 3

PhD: (Antioxidant medicinal plants), DST-Bose Institute, Kolkata, India, 2013

Post Doctoral Training: Post-Doctoral Research Fellow, Neurovirology, National Brain Research Centre, Manesar, Haryana, India. 2013-2019

Publications

A. Research Articles

1. Hazra, B., Chakraborty, S., Bhaskar, M., Mukherjee, S., Mahadevan, A., Basu, A. (2019). miR-301a regulates inflammatory response to Japanese Encephalitis Virus infection via suppression of NKRF activity. Journal of Immunology, 203(8): 2222-2238.

2. Mukherjee, S., Akbar, I., Bhagat, R., Hazra, B., Bhattacharyya, A., Seth, P., Roy, D., Basu, A. (2019) Identification and classification of hubs in miRNA target gene networks in human neural stem/progenitor cells following Japanese encephalitis virus infection. mSphere, 4(5), pii: e00588-19.

3. Philkhana, S. C., Verma, A. K., Jachak, G. R., Hazra, B., Basu, A., Reddy, D. S. (2017) Identification of new anti-inflammatory agents based on nitrosporeusine natural products of marine origin. European Journal of Medicinal Chemistry, 135: 89-109.

4. Hazra, B., Kumawat K. L., Basu, A. (2017) The host microRNA miR-301a blocks the IRF1-mediated neuronal innate immune response to Japanese encephalitis virus infection. Science Signaling, 10 (466): eaaf5185.

5. Kumari, B., Jain, P., Das, S., Ghosal, S., Hazra, B., Trivedi, A. C., Basu, A., Chakrabarti, J., Vrati, S., Banerjee, A. (2016) Dynamic changes in global microRNAome and transcriptomereveal complex miRNA-mRNA regulated host response to Japanese Encephalitis Virus in microglial cells. Scintific Reports, 6:20263. doi: 10.1038/srep20263.

6. Handore, k. L., Jadhav, P. D., Hazra, B., Basu, A., Reddy, D. S. (2015) Total Syntheses and Biological Evaluation of (±)-Botryosphaeridione, (±)-Pleodendione, 4-epi-Periconianone B, and Analogues. ACS Medicinal Chemistry Letters, 6 (11): 1117-1121.

7. Ghate, N. B., Hazra, B., Sarkar, R., Chaudhuri, D. and Mandal, N. (2014) Alteration of Bax/Bcl-2 ratio contributes to Terminalia belerica induced apoptosis in human lung and breast carcinoma. In Vitro Cellular and Developmental Biology Animal, 50: 527-537.

8. Hazra, B., Sarkar, R. and Mandal, N. (2013) The stem bark extract of Spondias pinnata lessens iron overload induced liver toxicity due to hemosiderosis in Swiss albino mice. Annals of Hepatology, 12: 123-129.

9. Hazra, B., Sarkar, R., Biswas, S. and Mandal, N. (2010) Comparative study of the antioxidant and reactive oxygen species scavenging properties in the extracts of the fruits of Terminalia chebula, Terminalia belerica and Emblica officinalis. BMC Complementary and Alternative Medicine, 10:20 doi:10.1186/1472-6882-10-20.

10. Hazra, B., Biswas, S. and Mandal, N. (2008) Antioxidant and free radical scavenging activity of Spondias pinnata. BMC Complementary and Alternative Medicine, 8:63 doi:10.1186/1472-6882-8-63.

B. Reviews:

1. Nazmi, A., Dutta, K., Hazra, B., Basu, A. (2014) Role of pattern recognition receptors in flavivirus infections. Virus Research, 185: 32-40.

C. Editorial:

1. Hazra, B., Chakraborty, S., Basu, A. (2017) miR-301a mediated immune evasion by Japanese encephalitis virus. Oncotarget, 8 (53): 90620-90621.

D. Book chapter:

1. Hazra, B., Sarkar, R., Biswas, S. and Mandal, N. (2014) Comparative study of the antioxidant and reactive oxygen species scavenging properties in the extracts of the fruits of Terminalia chebula, Terminalia belerica and Emblica officinalis: In Recent Advances in Plant-Based, Traditional,and Natural Medicines. Chapter 10, Edited by Vemulpad, S. and Jamie, J. Apple Academic Press, New Jersey, 181-213.

Awards and Honors:

2014-present: Associate Faculty member in the Faculty of 1000 in the section Neurological Disorders- Infectious Diseases of the Nervous System.

Research Associate (2014-2017): Plant growth regulator induced mitigation of heavy metal toxicity in Artemisia annua: physiological and biochemical responses of in vitro grown plant.

Research Fellow (2007-2012): Identification of effector proteins implicated in resistance for Yellow Mosaic Disease through proteomic approach. 

A. Journal Articles

1. Kundu S, Das A, Ghosh B (2016). Optimized extraction of artemisinin from Artemisia annua L. and corroborated quantitative analysis using High Performance Thin Layer Chromatography. Journal of Planar Chromatography 29 (5): 341–346. 

2. Kundu S, Haque SM, Ghosh B (2015). Comparative analysis of bioactive compounds in different habitat of Centella asiatica (L.) Urban: Application for in vitro clonal propagation of elite ecotype. Journal of Applied Pharmaceutical Science 5 (Suppl 2): 030-036. DOI: 10.7324/JAPS.2015.58.S5

3. Haque SM, Kundu S, Das A, Ghosh B (2015). In vitro mass propagation and synthetic seed production combined with phytochemical and antioxidant analysis of Bacopa chamaedryoides: An ethno-medicinally important plant. Asian Journal of Pharmaceutical and Clinical Research 8(2): 377-383.

4. Kundu S, Chakraborty D, Kundu A, Pal A (2013). Proteomics approach combined with biochemical attributes to elucidate compatible and incompatible plant-virus interactions between Vigna mungo and Mungbean Yellow Mosaic India Virus. Proteome Science 11: 15. 

5. Kundu S^*, Chakraborty D^* Das K, Pal A (2013). An efficient in-gel digestion protocol for mass spectral analysis by MALDI-TOF-MS and MS/MS and its use for proteomic analysis of leaves of Vigna mungo. Plant Molecular Biology Reporter 31: 47–54. [Impact factor 1.336]

6. Kundu S^*, Chakraborty D^*, Pal A (2011). Proteomic analysis of salicylic acid induced resistance to Mungbean Yellow Mosaic India Virus in Vigna mungo. Journal of Proteomics 2011; 74: 337–349. [Impact factor 3.509]

7. Maiti S^*, Kundu S^*, Chakraborty D, Paul S, Sengupta S, Das K and Pal A (2011). Developmentally regulated temporal expression and differential acid invertase activity in differentiating cotyledonary explants of mungbean [Vigna radiata (L.) Wilczek]. Plant Cell Tiss Organ Cult 107: 417–425. [Impact factor 2.196]

*Both have equal contribution.

B. Book Chapters

1. Kundu S, Haque SM, Ghosh B (2021) In vitro Exploitation of Medicinal Plants for Continuous Supply of Antidiabetic Bioactive Compounds Biotechnology of Anti-diabetic Medicinal Plants (978-981-16-3528-1) Springer Nature Singapore Pte Ltd. pp 25-64. DOI: 10.1007/978-981-16-3529-8_2

2. Das A, Kundu S, Ghosh B (2020) Assessment of plant genetic resources of chili germplasm. Sustainable resource Management (ISBN 9781774635117) Apple Academy Press, Inc. pp 289-336.

3. Chakraborty A, Kundu S, Mukherjee S, Ghosh B (2019) Endophytism in Zingiberaceae: Elucidation of Beneficial Impact. Endophytes and Secondary Metabolites, Reference Series in Phytochemistry (ISBN 978-3-319-90485-6), Springer International Publishing Switzerland, pp 187-212. DOI: 10.1007/978-3-319-76900-4_31-1

4. Ghosh B, Maiti R, Sarkar NC, Alam M Kundu S (2018) Climate change and its impact on crop productivity. Research trends in bioresource management and technology (ISBN: 978-1-63181-981-0). American academic press pp 106-135.

5. Ghosh B, Maiti R, Sarkar NC, Kundu S, Chakraborty T (2018) Medically bioactive natural molecules from plant bioresources. Research trends in bioresource management and technology (ISBN: 978-1-63181-981-0). American academic press pp 371-408.

6. Kundu S, Mukherjee S, Ghosh B (2016) Antimalarial Compound Synthesis from Transgenic Cultures. Transgenesis and Secondary Metabolism, Reference Series in Phytochemistry (ISBN: 978-3-319-27490-4), Springer International Publishing Switzerland, pp 123-152. DOI: 10.1007/978-3-319-27490-4_22-1.

7. Kundu S, Jha S, Ghosh B (2016) Metabolic Engineering for Improving Production of Taxol. Transgenesis and Secondary Metabolism, Reference Series in Phytochemistry (ISBN: 978-3-319-27490-4), Springer International Publishing Switzerland, pp 463-484. DOI: DOI 10.1007/978-3-319-28669-3_29.

Master’s specialization in: Taxonomy and Biosystematics, under Scottish Church College, University of Calcutta.

Ph.D in Molecular Mycopathology, under West Bengal State University in Department of Botany.

               Ph.D Thesis Title: Isolation, characterization of entomopathogenic fungi Beauveria bassiana (Balsamo) Vuillemin from different natural sources and their application as biocontrol agents against shoot and fruit borer insect (Leucinodes orbonalis Guen.) and growth promoting organism of Brinjal (Solanum melongena L.)

Research experience:

               Working as Junior Research Fellow for three years (2011-2014) in a DST(WB) sponsored project; entitled “Isolation, Characterization of fungi from different natural sources and their application as biocontrol agent against shoot and fruit borer insect of brinjal” at Ramakrishna Mission Vivekananda Centenary College, Rahara.

               Working as Senior Research Fellow for three years (2016-2019) in a DST(WB) sponsored project; entitled “Evaluation of different edible and medicinal fruit bodies of fungi (mushrooms) for antioxidant in vitro and anticancer agents in Human Cervical and Pancreatic cell lines among the poor schedule caste woman of West Bengal.”at Ramakrishna Mission Vivekananda Centenary College, Rahara.

Total Published Full papers in peer review International /National Journal: 19

Publication of last Five years

1.      Ghosh, SK. and Pal, S. 2017. Growth promotion and Fusarium wilt disease  management  in Chickpea  by Trichoderma  viride, Int.J.Curr.Res.Aca.Rev., 5(1): 14-26.  

2.      Ghosh, SK. Pal, S. Banerjee, S. 2017. Current Status Of Bacterial Diseases of Mulberry Plants, Crop Loss And Crop Protection, J. of Basic & Applied Science  International, 22 (3):105-110.

3.      Pal, S. and Ghosh, SK.  2017.  Extracellular Protease Production By Entomopathogenic Fungus Beauveria Bassiana And Its Compatibility Test Against Detergent And Surfactant. Plant Cell Biothechnology and Molecular Biology, 18(7&8):366-372

4.      Ghosh, SK. Banerjee,S. Pal, S.  Chakrabarty, N. 2018. Encountering epidemic effects of leaf spot disease (Alternaria brassicae) on Aloe vera by fungal biocontrol agents in agrifields - an ecofriendly approach. PLoS ONE 13(3): e0193720.

5.      Kar, R. and Pal, S. 2020. Medico Ethnobotanical Study of Antimicrobial Effects And Other Health Benefits on Nine Devine Plants of Navapatrika. International Journal of Engineering Applied Sciences and Technology, 5(3):377-382,.

6.      Ghosh, SK. Bera, T. Pal, S. 2020. Antiproliferative, Apoptotic, and Antimigration Property of Ethyl Acetate Extract of Calocybe indica against HeLa and CaSki Cell Lines of Cervical Cancer, and its Antioxidant and Mycochemistry Analysis. Middle East Journal of Cancer, 11(4): 454-468.

7.      Pal, S. 2020. Cultural hybridization of Brinjal cultivation in India: a review, Journal of Environment and sociobiology, 17 (2): 79-81.

8.      Ghosh, SK. and Pal, S. 2021. De-polymerization of LDPE plastic by Penicillium simplicissium isolated from municipality garbage plastic and identified by ITSs locus of rDNA. Vegetos, 34, 57–67.

Published Book Chapter

1.                Pal, S. and Ghosh, SK. 2018. Estimation of IAA (PGR) production induced by Beauveria bassiana in brinjal (Solanum melongena) for sustainable cultivation, Proceeding of WBHEDSTBT sponsored National seminar on Biotechnology in Human Health and Environment  ISBN:978-93-80736-83-9 Page143-147,Dept. of Zoology, Seth Anandram Jaipuria College, Kolkata,W.B.

2.                Pal, S. and Ghosh, SK. 2018. Phosphate solubilization study of Entomopathogenic  fungi Beauveria bassiana (Bals.) Vuill. and its effects on brinjal plant (Solanum melongena L.) growth. Book chapter of Biotechnology and Nature. Page:109-121. ISBN 978-93-87602-66-3

3.                Pal, S. 2019. Ethno-mycological Exploration of Mushroom from Ancient Indian Subcontinent: An Ethnobotanical Review. In Medicinal Plants of India: Conservation and sustainable use. Edt. by Tripathi et al. Today & Tomorrow’s printers and publishers, New Delhi. Book Chapter -17: 293-308. ISBN:978817 96525.

I did my PhD in Biochemistry from Bose Institute, Kolkata (2011-2019). There I worked on dissecting the transcriptional crosstalk between Heat-shock Response Pathway & Anti-Oxidant Response Pathway and how these two work in synergy to minimize genotoxic damage inflicted during Cancer Chemotherapy.

Post-Doctoral Experience: Worked as a DBT-Research Associate (2019 - 2021), mentored by Dr. Benu Brata Das at School of Biological Sciences, IACS, Kolkata. My work focused on unraveling the mechanism of Topoisomerase II mediated DNA double-strand break-and-rejoining in the mitochondria of mammalian cells and its implication in cancer chemotherapy.

Publication Details :

1. Paul, S., Ghosh, S., Mandal, S., Sau, S., Pal, M. (2018) NRF2 transcriptionally activates the heat shock factor 1 promoter under oxidative stress and affects survival and migration potential of MCF7 cells. J Biol Chem, 293, 19303-19316.

2. Nelson, V. K., Ali, A., Dutta, N., Ghosh, S., Paul, S., Jana, M., Ganguli, A., Komarov, A.,  Dwivedi, V., Chatterjee, S., Jana, N. R., Lakhotia, S. C., Chakrabarti, G., Misra, A. K., Mandal, S. C., and Pal, M. (2016) Azadiradione ameliorates polyglutamine expansion disease in Drosophila by potentiating DNA binding activity of heat shock factor 1. Oncotarget 7, 78281-78296.